All medications
Biologics
Tocilizumab
Brand names: Actemra and biosimilars (Tofidence, Tyenne)
A biologic that blocks the IL-6 receptor, a major inflammation pathway.
Video lesson
Animated explainer
What it’s used for
Rheumatoid arthritis, giant cell arteritis, systemic sclerosis lung disease and some other inflammatory conditions.
How it works
It sits on the IL-6 receptor so IL-6 cannot deliver its inflammatory message.
How it’s taken
An IV infusion every 4 weeks or an injection under the skin every 1 to 2 weeks.
Side effects
Higher infection risk, raised cholesterol and liver enzymes, low white counts, and rarely bowel perforation in people with diverticulitis.
Monitoring
Blood counts, liver tests and cholesterol. Note: it suppresses CRP and fever, so infections can look milder than they are.
Good to know
Tell any doctor treating you for infection that you take an IL-6 blocker.
At a glance
Class
Biologics
Brand names
Actemra and biosimilars (Tofidence, Tyenne)
Reviewed by Farhan Tahir, MD, FACR
Questions about your own care?
Book an in-person or telehealth consultation with Dr. Tahir.
For education only. Don’t start, stop or change a medicine without talking to your care team.