All medications
Biologics
Adalimumab
Brand names: Humira and biosimilars (Amjevita, Cyltezo, Hadlima, Hyrimoz, Yuflyma, Simlandi, Idacio and others)
A TNF inhibitor biologic that blocks one of the main drivers of inflammation in arthritis.
Video lesson
Animated explainer
What it’s used for
Rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, Crohn’s disease, ulcerative colitis, uveitis and psoriasis.
How it works
It is an antibody that binds TNF, a key inflammatory messenger, so it cannot switch on inflammation.
How it’s taken
An injection under the skin every 2 weeks, using a pen or prefilled syringe.
Side effects
Injection-site reactions, colds and sinus infections, and a higher risk of serious infections including reactivated tuberculosis. Rarely, nerve inflammation or lupus-like rash.
Monitoring
TB and hepatitis B screening before starting, then regular check-ins and blood tests.
Good to know
Pause doses during a serious infection and before major surgery. Avoid live vaccines. Biosimilars work the same way as the original.
At a glance
Class
Biologics
Brand names
Humira and biosimilars (Amjevita, Cyltezo, Hadlima, Hyrimoz, Yuflyma, Simlandi, Idacio and others)
Reviewed by Farhan Tahir, MD, FACR
Questions about your own care?
Book an in-person or telehealth consultation with Dr. Tahir.
For education only. Don’t start, stop or change a medicine without talking to your care team.