All medications
Biologics
Belimumab
Brand names: Benlysta
The first biologic approved for lupus, which reduces the survival signals B cells depend on.
Video lesson
Animated explainer
What it’s used for
Systemic lupus and lupus nephritis, added to standard therapy.
How it works
It binds BLyS (BAFF), a protein that keeps B cells alive, so overactive B cells decline.
How it’s taken
A weekly injection under the skin or an IV infusion every 4 weeks.
Side effects
Nausea, diarrhea, infections, infusion reactions and, rarely, mood changes.
Monitoring
Regular lupus labs and attention to mood.
Good to know
It can lower flare rates and help reduce steroid doses over time.
At a glance
Class
Biologics
Brand names
Benlysta
Reviewed by Farhan Tahir, MD, FACR
Questions about your own care?
Book an in-person or telehealth consultation with Dr. Tahir.
For education only. Don’t start, stop or change a medicine without talking to your care team.